4,4′-Methylenedianiline(MDA, also known as 4,4′-Diaminodiphenylmethane, CAS:101-77-9) is a light brown crystalline solid with a faint amine odor. It is very slightly soluble in water and soluble in alcohol, benzene, and ether. It is combustible when exposed to heat or flame. When heated to decomposition, it emits toxic fumes of aniline and nitrogen oxides (NOx). It is estimated that the 4,4′-methylenedianiline produced domestically is 40%-70% pure, while the imported product is approximately 98% pure. The dihydrochloride is a crystalline solid that is soluble in water. No other data were available.
Applications
Approximately 98% of the 4,4′-methylenedianiline produced domestically is used as a chemical intermediate in the closed-system production of isocyanates and polyisocyanates. These are used extensively in the manufacture of rigid polyurethane foams for insulation and semiflexible polyurethane foams for automobile safety cushioning. MDA is also used in the production of wire coatings, in the determination of tungsten and sulfates, as an analytical reagent, a corrosion inhibitor, and a monomer for polyamide and polyimide resins. No data were available on the use of the dihydrochloride other than its use as a research chemical.
Research On Carcinogenicity
There is sufficient evidence for the carcinogenicity of MDA and its dihydrochloride in experimental animals. When administered in the drinking water, 4,4′-methylenedianiline dihydrochloride increased the incidences of thyroid follicular cell carcinomas and neoplastic nodules of the liver in male rats; follicular cell and C-cell adenomas of the thyroid gland in female rats; thyroid follicular cell adenomas and hepatocellular carcinomas in mice of both sexes, adrenal pheochromocytomas in male mice; and hepatocellular adenomas and malignant lymphomas in female mice. In a study in rats in which MDA was administered orally in conjunction with a known carcinogen, the incidence of thyroid tumors was greater than that produced by the carcinogen alone.
MDA Drug
It is not well-known that MDA is also a schedule one drug in the United States, which means that the law considers it illegal with no legitimate medical use. However, ITdoes have an underground drug following. Side effects can potentially cause death or very serious health problems. It can cause severe liver damage in as little as one dose, reports the US EPA. 4,4′-methylenedianiline may also result in vomiting, muscle cramps, jaundice, and general weakness.
The US EPA reports that there are no known clinical trials on the long-term effects of MDA in humans. However, long-term exposure in rats is associated with an increased incidence of tumors.
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