Piroxicam(also known as Baxo or Erazon) is a non-steroidal anti-inflammatory drug used to ease the pain and swelling caused by arthritis. It works by reducing the amount of prostaglandins in the body, which is the substance that causes some types of painful swelling and fever. While many people experience few or no side effects, there is a potential for minor or serious side effects, and there are some precautions that must be taken while using the drug.
Nonsteroidal anti-inflammatory drugs(NSAIDs) like piroxicam, referred to as “cox inhibitors” because they block the actions of the cyclooxygenase enzymes COX-1 and COX-2, are used to reduce TCC-related bladder inflammation caused by the prostaglandins that COX-2 produces in the presence of inflammation. Although the connection is not entirely understood, veterinarians are finding that this medication may increase tumor cell death and negatively impact the development of the tumor’s supportive blood vessels in certain cancers; in layman’s terms, veterinarians think it increases cancer survival times. It is not commonly prescribed by veterinarians for pain relief.
Medical protocols combine piroxicam with chemotherapeutic drugs, such as cisplatin or mitoxantrone, to treat TCC, skin and oral squamous-cell carcinoma, prostatic carcinoma and certain abnormal rectal growths. The average survival time of dogs treated with a combination of piroxicam and cisplatin for oral squamous-cell carcinoma has risen to close to eight months. The average survival time of canine TCC patients treated with the medicine and mitoxantrone is just under one year, according to author and veterinarian Barbara Forney.
There are a number of medications that may interact with piroxicam, so it is important that a patient tell the prescribing doctor about all medicine and supplements taken, including over the counter medicines, vitamins, and supplements. Blood thinning medications, such as warfarin, ibuprofen, other NSAIDs, and oral steroids, may increase the risk of adverse side effects. Piroxicam usp(CAS number is 36322-90-4) may increase the toxicity of lithium, cyclosporine, methotrexate, and other drugs, so patients taking these drugs will need to be carefully monitored.
Serious side effects are an increased risk of heart attack, stroke, ulcers, and bleeding or tears in the gastrointestinal tract. Patients taking NSAIDs should seek immediate medical attention if they experience pain in the chest, weakness in one side or area of the body, difficulty breathing, or slurred speech, as these symptoms may indicate a heart attack or stroke. Stomach pain, heartburn, bloody vomit, vomit that looks like coffee grounds, or black or bloody stools may indicate serious gastrointestinal side effects, and medical attention should be sought right away.
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